Quinazolinone compounds as anticancer agents

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 239/90 (2006.01) A61K 31/505 (2006.01) A61P 35/00 (2006.01) C07D 401/06 (2006.01)

Patent

CA 2546932

Quinazolinone compounds, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the quinazolinone compounds, either alone or in combination with at least one additional therapeutic agent. Methods of using the quinazolinone compounds, either alone or in combination with at least one additional therapeutic agent as KSP inhibitors, in the prophylaxis or treatment of proliferative diseases.

L'invention concerne des composés quinazolinone, des sels pharmaceutiquement acceptables et des promédicaments de ces composés, ainsi que des compositions contenant un excipient pharmaceutiquement acceptable et un ou plusieurs desdits composés quinazolinone, seul(s) ou en association avec au moins un agent thérapeutique supplémentaire. La présente invention se rapporte également à des procédés d'utilisation des composés quinazolinone, seuls ou en association avec au moins un agent thérapeutique supplémentaire, en tant qu'inhibiteurs de KSP, pour prévenir ou traiter des maladies impliquant une prolifération.

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