A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/19 (2006.01) A61K 31/192 (2006.01) A61K 31/195 (2006.01)
Patent
CA 2370653
The present invention provides novel pharmaceutical compositions and methods of treatment that utilize or comprise tetrac and/or another thyromimetic compound. The parmaceutical compositions of the invention are capable of suppressing TSH secretion without inhibiting the pituitary specific monodeiodinase type II and while reducing or avoiding the thyromimetic stimulation of peripheral tissues compared to equivalent TSH-suppressive doses of L-thyroxine (T4). The pharmaceutical compositions of the invention are particularly useful for treating patients suffering from malignancy or abnormal growth of the thyroid and for preventing growth of residual thyroid tissue post thyroidectomy.
L'invention concerne de nouvelles compositions pharmaceutiques et techniques de traitement qui utilisent ou comportent du tétrac et/ou un autre composé thyromimétique. Lesdites compositions pharmaceutiques, comparées aux doses de L-thyroxine (T4) de suppression de TSH équivalentes, permettent de supprimer la sécrétion de TSH sans inhiber le type II spécifique de la monodésiodase pituitaire, tout en réduisant ou en évitant la stimulation thyromimétique des tissus périphériques. Lesdites compositions pharmaceutiques sont particulièrement utiles pour le traitement de patients souffrant de malignité ou de croissance anormale de la thyroïde et pour la prévention de la croissance de tissu thyroïdal résiduel après une thyroïdectomie.
Burger Albert
Danforth Elliot Jr.
Burger Albert
Danforth Elliot Jr.
Dimock Stratton Llp
LandOfFree
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