Rna sequence motifs in the context of defined...

Details Rna sequence motifs in the context of defined... Rna sequence motifs in the context of defined...

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/7105 (2006.01) A61K 39/39 (2006.01) A61P 11/06 (2006.01) A61P 37/04 (2006.01)

Patent

CA 2696630

Immunostimulatory polymers that contain certain sequence-dependent immunostimulatory RNA motifs and methods for the use of such immunostimulatory polymers and compositions containing such polymers are provided according to the invention. The sequence-dependent immunostimulatory RNA motifs and the polymers incorporating such motifs are potent and selective inducers of TLR7 and the TLR7- associated cytokine IFN-.alpha..

L'invention porte sur des polymères immunostimulateurs qui contiennent certains motifs d'ARN immunostimulateurs dépendant d'une séquence, sur des procédés pour l'utilisation de tels polymères immunostimulateurs et sur des compositions contenant les polymères selon l'invention. Les motifs d'ARN immunostimulateurs dépendant d'une séquence et les polymères comprenant de tels motifs sont des inducteurs puissants et sélectifs de TLR7 et de la cytokine IFN-a associée à TLR7.

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