A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/51 (2006.01) A61K 31/704 (2006.01)
Patent
CA 2644411
The present invention relates to a system for targeted active substance delivery for administering a pharmacologically active substance to the central nervous system of a mammal across the blood-brain barrier, where the system for targeted drug delivery comprises nanoparticles of PoIy(DL-lactide) and/or PoIy (DL-lactide-co-glycolide, and at least one pharmacologically active substance which is absorbed in the nanoparticles, is adsorbed thereon or is incorporated therein, and either comprises TPGS or includes a coating of the surface-active substance Pluronic 188, which is deposited on the nanoparticles loaded with active substance, and to methods for producing the system for targeted active substance delivery and to the use of the system for targeted active substance delivery for the treatment of a disease or an impairment of the central nervous system.
La présente invention concerne un système d'alimentation ciblée de substances actives pour l'administration d'une substance pharmacologiquement active sur le système nerveux central d'un mammifère au travers de la barrière hémato-encéphalique, le système d'administration ciblée de médicament comprenant une nanoparticule constituée de poly(DL-lactide) et/ou de poly(DL-lactide-co-glycolide) et d'au moins une substance pharmacologiquement active, absorbée dans la nanoparticule, adsorbée à sa surface ou incorporée dans son volume, et soit contenant du TPGS, soit présentant un revêtement du tensioactif Pluronic 188, qui est isolé sur la particule chargée de substance active. L'invention concerne également un procédé de fabrication du système d'administration ciblée de substances actives et l'utilisation du système pour l'administration ciblée de substances actives pour le traitement d'une maladie ou d'un trouble du système nerveux central.
Gelperina Svetlana
Khalanskiy Alexander
Kreuter Joerg
Maksimenko Olga
Blake Cassels & Graydon Llp
Lts Lohmann Therapie-Systeme Ag
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