A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61K 39/395 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2627981
The present invention provides reagents, methods and systems for predicting the cytotoxic activity of an antibody or variant thereof comprising: determining a binding affinity of the antibody or variant thereof to a Fc activating receptor; determining a binding affinity of the antibody or variant thereof to a Fc inhibitory receptor, and calculating the ratio of said activating binding affinity to said inhibitory binding affinity (A/I ratio) , wherein the magnitude of said ratio is an indication of the cytotoxic activity of the antibody or variant thereof . The present invention also provides purified modified antibodies having altered A/I ratios as compared to the unmodified antibodies.
La présente invention concerne des réactifs, des procédés et des systèmes pour la prédiction de l'activité cytotoxique d'un anticorps ou d'une variante, comprenant : la détermination d'une affinité de liaison de l'anticorps ou de sa variante avec un récepteur activateur Fc, la détermination d'une affinité de liaison de l'anticorps ou de sa variante avec un récepteur inhibiteur Fc, et le calcul du ratio de ladite affinité de liaison sur ladite affinité inhibitrice (ratio A/I), selon laquelle l'ampleur du ratio atteste de l'activité cytotoxique de l'anticorps ou de sa variante. L'invention concerne en outre des anticorps modifiés purifiés aux ratios A/I altérés par rapport aux anticorps non modifiés.
Falk Nimmerjahn
Ravetch Jeffrey
Oyen Wiggs Green & Mutala Llp
The Rockefeller University
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