Enhancement of antibody-cytokine fusion protein mediated...

A - Human Necessities – 61 – K

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A61K 39/395 (2006.01) A61K 31/282 (2006.01) A61K 31/337 (2006.01) A61K 31/675 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61P 35/00 (2006.01) C07K 16/30 (2006.01) C07K 19/00 (2006.01)

Patent

CA 2412845

Disclosed are methods and compositions for treating tumors. Disclosed methods and compositions enhance the uptake of immunocytokines into tumors, and are based on a combination of an immunocytokine with an immunocytokine uptake enhancing agent. Disclosed methods and compositions are particularly useful for reducing tumor size and metastasis in a mammal.

La présente invention concerne des méthodes et des compositions destinées à la cancérothérapie. Ces méthodes et ces compositions améliorent la fixation des immunocytokines sur les tumeurs, et reposent sur une association d'immunocytokines et d'agent améliorant la fixation des immunocytokines. Ces méthodes et ces compositions sont particulièrement utiles dans la réduction de la taille des tumeurs et des métastases chez les mammifères.

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