Stabilized aqueous compositions comprising tissue factor...

Details Stabilized aqueous compositions comprising tissue factor... Stabilized aqueous compositions comprising tissue factor...

A - Human Necessities

61

K

A61K 38/57 (2006.01) A61K 47/12 (2006.01) A61K 47/18 (2006.01) C07K 14/81 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2512681

Stabilized aqueous compositions of tissue factor pathway inhibitor (TFPI) or TFPI variants comprise a solubilizing agent, an antioxidant, and a buffer. The combination of a solubilizing agent and an antioxidant can lead to a significant improvement in the storage life of TFPI or TFPI variant compositions. The solubilizing agent and antioxidant substantially counteract the effects of TFPI or TFPI variant degradation through aggregation and oxidation.

L'invention porte sur des compositions aqueuses stabilisées de TFPI (inhibiteur de la voie du facteur tissulaire) ou ses variantes, comprenant un agent solubilisant, un antioxydant et un tampon. La combinaison d'un agent solubilisant et d'un antioxydant peut conduire à une amélioration significative de la durée de conservation desdites compositions car elle contrecarre la dégradation du TFPI ou de ses variantes par agrégation et oxydation.

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