Isoquinoline derivatives having kinase inhibitory activity...

Details Isoquinoline derivatives having kinase inhibitory activity... Isoquinoline derivatives having kinase inhibitory activity...

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4725 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2502583

It is intended to provide a compound which is useful in treating a disease mediated by Rho kinase because of having an Rho kinase inhibitory effect. Namely, a compound of the following general formula (I), its pharmaceutically acceptable salt or a solvate thereof: (I) wherein Q represents phenyl, pyridyl, pyrrolyl, thienyl or furyl optionally having one or two substituents selected from among halogens, alkyls, nitro and amino; and p is 2 or 3.

L'invention concerne un composé utilisé dans le traitement d'une maladie médiée par la Rho kinase pour son effet inhibiteur sur la Rho kinase, à savoir un composé représenté par la formule générale suivante (I), son sel acceptable d'un point de vue pharmaceutique ou un solvate de celui-ci, formule dans laquelle Q représente phényle, pyridyle, pyrrolyle, thiényle ou furyle, contenant éventuellement un ou deux substituants sélectionnés parmi les halogènes, les alkyles, nitro et amino, et p est 2 ou 3.

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