A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/46 (2006.01) A61K 38/48 (2006.01)
Patent
CA 2489997
A method is provided for the localized intravascular administration of a fibrinolytic metalloproteinase to a human subject in amounts that are both safe and effective to lyse an occluding fibrin-containing blood clot, while also avoiding the neutralizing effects of .alpha.2-macroglobulin in the circulating blood. A method is also provided for the treatment of a blood clot in, around or attached to an indwelling vascular access device. A method for restoring patency and function of an indwelling vascular access device is also provided.
L'invention concerne une méthode destinée à l'administration intravasculaire localisée d'une métalloprotéinase fibrinolytique à un sujet humain en doses inoffensives et efficaces pour lyser un caillot de sang occlusif contenant de la fibrine, ladite méthode permettant d'éviter les effets de neutralisation de l'.alpha.¿2?-macroglobuline dans le sang circulant. L'invention concerne également une méthode destinée au traitement d'un caillot de sang dans, autour ou sur un dispositif d'accès vasculaire à demeure. Elle se rapporte en outre à une méthode permettant de rétablir la perméabilité et la fonction d'un dispositif d'accès vasculaire à demeure.
Amgen Inc.
Gowling Lafleur Henderson Llp
LandOfFree
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