Methods of detecting poly(adp-ribose) polymerase enzymatic...

Details Methods of detecting poly(adp-ribose) polymerase enzymatic... Methods of detecting poly(adp-ribose) polymerase enzymatic...

C - Chemistry, Metallurgy

12

Q

C12Q 1/48 (2006.01) C12Q 1/25 (2006.01) G01N 33/533 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2369408

The invention provides methods for assaying poly(ADP-ribose) polymerase (PARP) activity and methods for the identification of modulators of PARP activity. These methods comprise contacting immobilized PARP with NAD under conditions that allow PARP auto-ribosylation, contacting the auto- ribosylated PARP with a detectable marker to form a complex and then indirectly or directly measuring the amount of detectable marker bound to the auto- ribosylated PARP, this amount being indicative of PARP activity.

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