Antiviral, anti-infectious and cicatrising properties of...

A - Human Necessities – 61 – K

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A61K 36/48 (2006.01) A61P 17/02 (2006.01) A61P 31/00 (2006.01) A61P 31/18 (2006.01)

Patent

CA 2526901

The invention relates to Dichrostachys glomerata, a tropical African plant, sickle bush, from the Mimosaceae family, which is gathered at an altitude below 500 metres (leaves and branches with diameter of less than 2 centimetres) and which, after dehydration, is macerated for 45 minutes at 100 ·C in order to produce an antiviral substance known as Apivirine (100 kilograms producing 3,100 grams, pH of between 3 and 4, moisture content of less than 10 %). Apivirine reduces the viral load (undetectable result) and restores the immune system, mainly by re-establishing the level of CD4 lymphocytes, i.e. the master defence cell and the main target of HIV. In this way, Apivirine is an active antiretroviral agent which is immediately effective in relation to HIV/AIDS. Apivirine can be transformed into a medicament in any pharmaceutical industry. The daily dose for an adult is 30 grams which is administered in three divided doses (continuous treatment). The viral load and CD4 counting provide the biological parameters which confirm the anti-HIV effectiveness thereof. The invention can also be used to treat measles, ulcers and gynaecological diseases.

Dichrostachys glomerata, plante d'Afrique tropicale, Mimosa clochette, famille Mimosacée, récolté à une altitude inférieure à 500 mètres (feuilles et branches de diamètre inférieur à 2 centimètres), macéré pendant 45 minutes à 100 ·C donne après déshydratation une substance antivirale dénommée APIVIRINE (100 kilogrammes donnent 3100 grammes, PH compris entre 3 et 4, taux d'humidité inférieur à 10 %). Apivirine baisse la charge virale (résultat indétectable) et restaure le système immunitaire en rétablissant principalement le taux des lymphocytes CD4, cellule maîtresse de la défense, cible principale du VIH: c'est un principe actif antirétroviral d'efficacité immédiate sur le VIH/SIDA. Toute industrie pharmaceutique peut transformer Apivirine en médicament. La posologie journalière pour adulte est 30 grammes répartis en 3 prises (traitement continu). Les paramètres biologiques confirmant cette efficacité anti-VIH sont la charge virale et la numération des CD4. Elle traite aussi la rougeole, les ulcères et des affections gynécologiques.

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