C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/12 (2006.01) A61K 31/454 (2006.01) A61P 25/18 (2006.01)
Patent
CA 2682671
The present invention relates to [1- (benzyl) -piperidin-4-yl] -( [1, 3,4] thiadiazol-2-yl) - amine and [1- (benzyl) -piperidin-4-yl] - (thiazol-2-yl) -amine derivatives of formula (I) that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects.
Cette invention concerne des dérivés de [1- (benzyl) -pipéridin-4-yl] -( [1, 3,4] thiadiazol-2-yl) - amine et de [1- (benzyl) -pipéridine-4-yl] - (thiazol-2-yl) -amine, représentés par la formule (I), qui sont des antagonistes du récepteur 2 de la dopamine à dissociation rapide, des procédés de préparation de ces composés et des compositions pharmaceutiques contenant ces composés comme principe actif. Ces composés conviennent pour le traitement ou la prévention des troubles du système nerveux central, notamment de la schizophrénie, par l'action anti-psychotique qu'ils exercent sans effets secondaires moteurs.
Bartolome-Nebreda Jose Manuel
Macdonald Gregor James
Van Gool Michiel Luc Maria
Gowling Lafleur Henderson Llp
Janssen Pharmaceutica N.v.
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