Substituted pyridazinyl-and pyrimidinyl-quinolin-4-ylamine...

Details Substituted pyridazinyl-and pyrimidinyl-quinolin-4-ylamine... Substituted pyridazinyl-and pyrimidinyl-quinolin-4-ylamine...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4985 (2006.01) A61K 31/501 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) A61P 3/04 (2006.01) A61P 11/00 (2006.01) A61P 13/00 (2006.01) A61P 25/04 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2594998

Substituted pyridazinyl- and pyrimidinyl-quinolin-4-ylamine analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

L'invention concerne des analogues de pyridazinyl- et de pyrimidinyl-quinolin-4-ylamine substitués. Lesdits composés sont des ligands qui peuvent être utilisés afin de moduler l'activité de récepteurs spécifiques in vivo ou in vitro, et sont particulièrement utiles dans le traitement d'états associés à l'activation pathologique de récepteurs chez les humains, les animaux de compagnie et les animaux d'élevage. L'invention concerne également des compositions pharmaceutiques et des méthodes d'utilisation de ces dernières pour traiter lesdits troubles, ainsi que des méthodes d'utilisation desdits ligands pour des études de localisation de récepteurs.

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