Method of preparing aryl(homo)piperazines

Details Method of preparing aryl(homo)piperazines Method of preparing aryl(homo)piperazines

C - Chemistry, Metallurgy

07

D

C07D 295/04 (2006.01) C07D 213/74 (2006.01) C07D 243/08 (2006.01) C07D 295/033 (2006.01) C07D 319/18 (2006.01) C07D 333/36 (2006.01) C07D 401/04 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2089534

DIR 0501 ABSTRACT The present invention is concerned with a method for the preparation of a compound of the general formula 2 Image (2) by reaction of a compound of the formula 3 Ar-Y (3) with a compound of the general formula 4 Image (4) wherein Ar means a (hetero)aryl group, preferably selected from phenyl, naphtyl, furyl, thienyl, pyridyl, bicylic heteroaryl and tricyclic heteroaryl, which (hetero)aryl group is optionally sustituted with one to five non-strongly- electron-withdrawing substituents; M is a metal from the groups I or II of the periodic table; R12 is an electronegative group; and n is 0 or 1. The invention also relates to compounds prepared according to this method and to new substituted aryl(homo)- piperazines.

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