Programmed cell death and caspase-12

Details Programmed cell death and caspase-12 Programmed cell death and caspase-12

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C12N 9/50 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2402599

This invention relates to nucleic aids according caspase-12, proteins encoded by camp-12 nucleic acids proteins, and hosts transformed with vectors. Caspase-12 is a member of the caspase family, which also includes mammalian interleukin-1.beta.-converting enzyme (ICE). Caspases are thought to carry out the execution phase of apoptosis in a cascade of proteolytic events. The invention also to the use of caspsae-12 to induce programmed cell death.

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