Human protein kinase c inhibitor homolog

Details Human protein kinase c inhibitor homolog Human protein kinase c inhibitor homolog

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2257528

The present invention provides a polynucleotide (ipkc) which identifies and encodes a novel human protein kinase C inhibitor homolog (IPKC). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding IPKC. The invention also provides for the use of purified IPKC and its agonists in the commercial production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the expression of IPKC. Additionally, the invention provides for the use of antisense molecules complementary to ipkc in pharmaceutical compositions for treatment of diseases associated with the expression of IPKC. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of ipkc. The present invention also relates to anti-IPKC antibodies which specifically bind to IPKC.

La présente invention concerne un polynucléotide (ipkc) qui identifie et code une nouvel homologue inhibiteur de protéine kinase C humaine (IPKC). On décrit des vecteurs d'expression et des cellules hôtes produits par génie génétique comprenant la séquence d'acide nucléique codant l'IPKC. On décrit également l'utilisation d'un IPKC purifié et de ses agonistes dans la production commerciale de protéines recombinées et dans des compositions pharmaceutiques pour le traitement de maladies associées à l'expression de l'IPKC. En outre, la présente invention concerne l'utilisation de molécules antisens complémentaires de l'ipkc dans des compositions pharmaceutiques pour le traitement de maladies associées à l'expression de l'IPKC. On décrit également des méthodes diagnostiques faisant appel à des compositions diagnostiques comprenant ledit polynucléotide, des fragments ou le complément de ce dernier, qui s'hybrident avec la séquence génomique ou le produit de transcription de l'ipkc. La présente invention concerne également des anticorps anti-IPKC qui se lient spécifiquement à l'IPKC.

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