Process for preparing enantiomerically pure tropic acid esters

Details Process for preparing enantiomerically pure tropic acid esters Process for preparing enantiomerically pure tropic acid esters

C - Chemistry, Metallurgy

07

D

C07D 451/12 (2006.01) C07D 451/10 (2006.01) C07D 451/14 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2219533

Precursors of anticholinergically active quaternary compounds can be synthesised from optically active tropic acid by acetylation, conversion into the acid chloride, reaction with amino alcohols of formula (I) (see formula I) (as the methanesulphonate; Q and R are explained in the specification), deacetylation and isolation of the reaction product.

On peut synthétiser des précurseurs de composés quaternaires anticholinergiques par acétylation d'acide tropique optiquement actif, par transformation des produits acétylés en chlorure d'acide, puis par leur réaction avec des aminoalcools ayant la formule (I), tel le sulfonate de méthane, Q et R étant expliqués dans la description, par désacétylation et par isolement du produit de la réaction.

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