Brca2 transcriptional activator domain and uses thereof

Details Brca2 transcriptional activator domain and uses thereof Brca2 transcriptional activator domain and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 14/82 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2288335

Exon 3 of BRCA2 encodes a transcriptional activator domain ("TAD"), including a primary activating region ("PAR") and an auxiliary activating region ("AAR"), flanked by two inhibitory regions ("IR1" and "IR2") which are bound by molecules which inhibit activation of transcription by the TAD. Appropriate fragments of BRCA2 polypeptide are useful in activating transcription and in assays for substances able to modulate transcriptional activation by BRCA2.

L'exon 3 de BRCA2 code un domaine de l'activateur transcriptionnel ("TAD") et comprend une région d'activation primaire ("PAR") et une région d'activation auxiliaire ("AAR") flanquées de deux régions inhibitrices ("IR1" et "IR2") liées par des molécules qui inhibent l'activation de transcription par TAD. Des fragments appropriés du polypeptide de BRCA2 sont utilisés dans la transcription d'activation et dans les dosages de substances capables de moduler l'activation transcriptionnelle effectuée par BRCA2.

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