A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/403 (2006.01) A61K 9/16 (2006.01)
Patent
CA 2530788
A stable composition of a 2-aza-bicyclo[3.3.0]-octane-3-carboxylic acid derivative and a method for its preparation are described. The stable composition includes an intimate admixture of the derivative and a stabilizing effective amount of a lubricant. The stable composition further includes an external excipient. A method of preparing the stable composition includes forming an intimate admixture of the derivative and a lubricant and then blending the intimate admixture with at least one excipient. Preferably the final blend is transformed into solid unit dosage form.
L'invention porte sur une composition stable d'un dérivé de l'acide 2-aza-bicyclo[3.3.0]-octane-3-carboxylique et sur son procédé de préparation. Ladite composition comporte un mélange intime du dérivé et une quantité efficace à effet stabilisant de lubrifiant et un excipient externe. L'invention porte également sur son procédé de préparation consistant à former un mélange intime du dérivé et du lubrifiant que l'on mélange à au moins un excipient. Le produit final est de préférence transformé en formes posologiques solides.
Hrakovsky Julia
Tenengauzer Ruth
Heenan Blaikie Llp
Teva Pharmaceutical Industries Ltd
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