Immunogenic polypeptides encoded by mage minigenes and uses...

Details Immunogenic polypeptides encoded by mage minigenes and uses... Immunogenic polypeptides encoded by mage minigenes and uses...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C12N 15/861 (2006.01) C12N 15/863 (2006.01)

Patent

CA 2408328

The invention discloses immunogenic polypeptides comprising several MAGE- specific antigen epitopes selected from different (i.e. discrete) members of the MAGE protein family, nucleic acids coding therefor, recombinant viruses and/or cells comprising said nucleic acids, and compositions thereof. Methods for eliciting or inducing MAGE-specific immune responses utilizing the aforementioned immunogenic agents are also disclosed.

L'invention concerne des polypeptides immunogéniques comprenant plusieurs épitopes antigéniques spécifiques aux MAGE sélectionnés parmi différents membres (c'est à dire distincts) de la famille des protéines MAGE, des acides nucléiques codant à cet effet, des virus et/ou des cellules recombinées contenant lesdits acides nucléiques, et leurs compositions. L'invention concerne également des méthodes de mise en lumière ou d'induction de réponses immunes spécifiques aux MAGE utilisant les agents immunogéniques précités.

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