Chondrocyte cell-lines

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 5/10 (2006.01) A61K 35/32 (2006.01) A61L 27/38 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01) C12N 15/85 (2006.01) C12Q 1/02 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2207764

The invention relates to chondrocytes and chondrocyte cell-lines for use especially in studying arthritic conditions and also for developing skeletal tissue for use in repair and/or replacement surgery. The use of articular chondrocyte cell-lines which mineralise calcium to determine potentially beneficial therapeutic agents is disclosed. Further, the means for producing such cell-lines is also disclosed as well as the characteristics of such cell- lines. The use of hypertrophic chondrocyte cell-lines to produce matrix tissue is also disclosed. Further means of producing hypertrophic chondrocyte cell- lines is also disclosed as well as the charateristics of such cell-lines.

La présente invention concerne des chondrocytes et des lignées cellulaires de chondrocytes prévues pour être utilisées dans l'étude des conditions arthritiques et également pour assurer le développement du tissu squelettique dans les actes de chirurgie réparatrice ou d'implantation de prothèses. L'invention concerne également l'utilisation de lignées cellulaires de chondrocytes articulaires qui minéralisent le calcium pour déterminer les agents thérapeutiques potentiellement bénéfiques. En outre, l'invention traite également des moyens de production de ces lignées cellulaires ainsi que des caractéristiques de ces lignées cellulaires. L'utilisation de lignées cellulaires de chondrocytes hypertrophiques pour produire des tissus matriciels est également décrite. En outre, d'autres moyens de production des lignées cellulaires de chondrocytes hypertrophiques sont décrits, ainsi que les caractéristiques de ces lignées cellulaires.

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