Process for preparing adrenaline

Details Process for preparing adrenaline Process for preparing adrenaline

C - Chemistry, Metallurgy

07

C

C07C 213/08 (2006.01) C07B 53/00 (2006.01) C07C 213/00 (2006.01) C07C 215/60 (2006.01)

Patent

CA 2381246

The present invention relates to an improved process for preparing adrenaline, or an addition salt thereof, on an industrial scale, with asymmetric hydrogenation as a key step and a special sequence of successive steps, using [Rh(COD)Cl]2 as catalyst and a chiral, bidentate phosphine ligand such as (2R, 4R)-4-(dicyclohexylphosphino)-2- (diphenylphosphino--methyl) -N-methyl-aminocarbonyl-pyrrolidine as the catalyst system.

Procédé amélioré de fabrication d'adrénaline ou d'un sel d'addition de ladite substance à l'échelle industrielle, qui comporte une hydrogénation asymétrique en tant qu'étape clé et une succession spéciale d'étapes suivantes, le catalyseur utilisé étant [Rh(COD)Cl]2 et un ligand phosphinique chiral bidenté tel que (2R, 4R)-4-(dicyclohexylphosphino)-2-(diphénylphosphino-méthyl)-N-méthyl-aminocarbonyl-pyrrolidine étant utilisé en tant que système catalyseur.

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