Markers for detection of gastric cancer

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2762082

Early detection of tumors is a major determinant of survival of patients suffering from tumors, including gastric tumors. Members of the GTM gene family can be differentially expressed in gastric tumor tissue, and thus can be used as markers for the detection of gastric and other types of cancer. The present invention provides for novel GTMs for the detection of tumors, including gastric tumors, and in particular human zymogen granule protein 16 (ZG16). The GTMs can be used in isolation or together with other known GTMs to provide for novel signatures to be used in the detection of tumors, including gastric tumors.

La détection précoce des tumeurs est un facteur majeur de survie des patients en étant atteints, dont les tumeurs gastriques. Les membres de la famille des gènes GTM peuvent être exprimés différentiellement dans les tissus des tumeurs gastriques et donc servir de marqueurs de détection de cancers gastriques et d'autres types de cancers. L'invention porte sur de nouvelles GTMs de détection de tumeurs dont les tumeurs gastriques et en particulier sur la protéine humaine de granule de zymogène 16 (ZG16) qui, seule ou associée à d'autres GTMs, produit de nouvelles signatures utilisables pour la détection de tumeurs dont les tumeurs gastriques.

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