Phenylurea derivatives used as inhibitors of tyrosinkinase...

Details Phenylurea derivatives used as inhibitors of tyrosinkinase... Phenylurea derivatives used as inhibitors of tyrosinkinase...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2584170

The invention relates to the compounds of formula (I), wherein R1a-R1e, R2a, R2b, R3 and X are defined as in claim 1. The inventive derivatives are tyrosinkinase inhibitors, especially inhibitors of TIE-2, and Raf kinase inhibitors and may inter alia be used for treating tumors.

La présente invention concerne des composés de formule (I) dans laquelle R1a-R1e, R2a, R2b, R3 et X ont les correspondances indiquées dans la revendication 1. Ces composés sont des inhibiteurs des tyrosine kinases, en particulier de TIE-2, et des inhibiteurs des Raf-kinases, et peuvent entre autres être utilisés pour traiter des tumeurs.

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