A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4439 (2006.01) A61K 31/225 (2006.01) A61P 1/04 (2006.01)
Patent
CA 2658804
The present invention is related to novel oral compositions comprising an irreversible gastric H+/K+-ATPase proton pump inhibitor (PPI) as a gastric acid secretion inhibitor and one or more aliphatic carboxylic acid derivative molecules which activate parietal cells, wherein the derivatives possess delayed or sustained enhancement effect on the PPI activity compared to the non-derivatized acid molecules. The present invention further relates to a method of using such compositions to reduce gastric acid secretion in a mammal.
La présente invention concerne de nouvelles compositions orales contenant un inhibiteur de la pompe à protons (IPP) agissant de manière irréversible comme anti-sécrétoire sur l'activité de l'ATPase H+K+ des cellules gastriques et une ou plusieurs molécules dérivées d'acide carboxylique aliphatique qui activent les cellules pariétales; les dérivés ont un effet renforçateur soutenu ou différé sur l'activité de l'IPP par rapport aux molécules d'acide non dérivées. La présente invention concerne en outre un procédé d'utilisation de ces compositions afin de réduire les sécrétions d'acide gastrique chez un mammifère.
Atorot Tal
Kostadinov Aleksey
Marash Michael
Ridout & Maybee Llp
Vecta Ltd.
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