Use of substituted 5-amino-1h-pyrrole-2-carbonitrile...

Details Use of substituted 5-amino-1h-pyrrole-2-carbonitrile... Use of substituted 5-amino-1h-pyrrole-2-carbonitrile...

A - Human Necessities

61

K

A61K 31/40 (2006.01) A61K 31/4025 (2006.01) A61K 31/569 (2006.01) A61K 45/06 (2006.01) A61P 5/34 (2006.01) A61P 5/36 (2006.01) A61P 13/08 (2006.01) A61P 15/08 (2006.01) A61P 15/12 (2006.01) A61P 15/18 (2006.01) A61P 35/00 (2006.01) C07D 207/34 (2006.01)

Patent

CA 2613518

The use of compounds of formula (I), or a pharmaceutically acceptable salt thereof, (I) wherein R1, R2, R3, R4, R5, R6 and R7, are as defined herein, for contraception, hormone replacement therapy, synchronizing estrus, treating dysmenorrhea, treating dysfunctional uterine bleeding, treating uterine myometrial fibroids, treating endometriosis, treating benign prostatic hypertrophy, treating carcinomas and adenocarcinomas of the endometrium, ovary, breast, colon, prostate, pituitary, and meningioma, inducing amenorrhea, cycle-related symptoms, or treating symptoms of premenstrual syndrome and premenstrual dysphoric disorder are described. Also provided are products containing these compounds.

L'invention porte sur l'utilisation de composés de formule (I) ou d'un sel de ceux-ci acceptable d'un point de vue pharmaceutique, formule dans laquelle R1, R2, R3, R4, R5, R6 et R7 sont tels que définis dans la demande, ces composés étant utiles dans la contraception, dans le traitement hormonal substitutif, la synchronisation de l'oestrus, le traitement de la dysménorrhée, le traitement de la ménométrorragie, le traitement des fibromes utérins, le traitement de l'endométriose, le traitement de l'hypertrophie bénigne de la prostate, le traitement des carcinomes et des adénocarcinomes de l'endométrium, des ovaires, du sein, du côlon, de la prostate, de l'hypophyse et du méningiome, induisant l'aménorrhée, les symptômes liés au cycle ou le traitement des symptômes du syndrome prémenstruel et du trouble dysphorique prémenstruel. L'invention porte également sur des produits contenant ces composés.

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