C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/34 (2006.01) A61K 31/415 (2006.01) A61K 31/785 (2006.01) A61K 38/00 (2006.01) A61K 38/04 (2006.01) A61K 49/00 (2006.01) A61P 43/00 (2006.01) C07D 233/90 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07K 7/02 (2006.01) C08G 69/00 (2006.01) C08G 69/08 (2006.01) C12Q 1/68 (2006.01) C12N 15/09 (2006.01)
Patent
CA 2281947
The invention encompasses improved polyamides for binding to specific nucleotide sequences in the minor groove of double stranded DNA. The 3-hydroxy- N-methylpyrrole/N-methylpyrrole carboxamide pair specifically recognizes the T.A base pair, while the N-methylpyrrole/3-hydroxy-N-methylpyrrole pair recognizes A.T nucleotide pairs. Similarly, an N-methylimidizole/N- methylpyrrole carboxamide pair specifically recognizes the G.C nucleotide pair, and the N-methylpyrrole/N-methylimidizole carboxamide pair recognizes the C.G nucleotide pair.
L'invention concerne des polyamides améliorés pour assurer une liaison à des séquences de nucléotides spécifiques, dans le sillon mineur d'un ADN à double brins. La paire de 3-hydroxy-N-méthylpyrrole/N-méthylpyrrole carboxamide reconnait manière spécifique la paire de basesT.A, tandis que la paire N-méthylpyrrole/3-hydroxy-N-méthylpyrrole reconnait les paires de nucléotides A.T. De la même manière, une paire N-méthylimidizole/N-méthylpyrrole carboxamide reconnait la paire de nucléotides G.C, et la paire N-méthylpyrrole/N-méthylimidizole carboxamide reconnait la paire de nucléotides C.G.
Baird Eldon E.
Dervan Peter B.
California Institute Of Technology
Smart & Biggar
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