C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/04 (2006.01) A61K 31/407 (2006.01) A61P 7/00 (2006.01) A61P 31/00 (2006.01)
Patent
CA 2663829
The present invention provides dithiolopyrrolone compounds of the general formula I, and their salts, wherein A is sulfur or carbon, and R1, R2, and R3 are selected from groups defined herein, and wherein when A is sulfur, then B is oxygen, and n = 1 or 2, and when A is carbon, then B is oxygen or sulfur, and n = 1. The compounds are useful for the prevention and treatment of microbial infections such as HIV infection, and for the treatment of blood disorders, such as neutropenia. In particular, the compounds are useful for the manufacture of medicaments for increasing white blood cells.
La présente invention concerne de nouveaux composés de dithiolopyrrolone et les sels de ces derniers qui favorisent la production de globules blancs et qui sont utiles dans la prévention et les traitements des infections microbiennes telles que l'infection par le VIH et les troubles du sang tels que la neutropénie et d'autres maladies apparentées. Cette invention concerne également des compositions thérapeutiques comprenant des types particulièrement utiles de dithiolopyrrolones, ainsi que leurs sels, des méthodes et l'utilisation de ces composés dans la préparation d'un médicament destiné au traitement de maladies.
Chen Genhui
Guo Yingping
Li Bin
Celestial Pharmaceuticals (shenzhen) Ltd.
Oyen Wiggs Green & Mutala Llp
Welichem Biotech Inc.
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