Methods for preserving ophthalmic solutions and preserved...

A - Human Necessities – 61 – K

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A61K 47/02 (2006.01) A01N 59/00 (2006.01) A01N 59/08 (2006.01) A61K 9/00 (2006.01) A61K 9/08 (2006.01) A61L 12/08 (2006.01) A61L 12/12 (2006.01) A61P 27/02 (2006.01)

Patent

CA 2470396

A method of inhibiting Cladosporium growth in an aqueous ophthalmic solution comprising a cellulose derivative and a hydrogen peroxide source, comprising: providing an aqueous solution comprising a cellulose derivative and a hydrogen peroxide source, wherein said solution will support Cladosporium growth if contaminated with Cladosporium; and admixing an effective amount of an alkaline earth metal salt with said solution to yield an alkaline earth metal- containing solution which, if contaminated with Cladosporium, will allow less Cladosporium growth than an otherwise identical solution that does not comprise an alkaline earth metal salt.

L'invention concerne un procédé d'inhibition de la croissance de Cladosporium dans une solution ophtalmique aqueuse renfermant un dérivé de cellulose et une source de peroxyde d'hydrogène, comprenant les étapes suivantes: l'apport d'une solution aqueuse renfermant un dérivé de cellulose et une source de peroxyde d'hydrogène, ladite solution prenant en charge la croissance de Cladosporium s'il y a contamination avec le Cladosporium; et le mélange d'une quantité efficace d'un sel de métal alcalino-terreux avec ladite solution afin d'obtenir une solution contenant un métal alcalino-terreux qui, en cas de contamination avec le Cladosporium, va réduire la croissance de Cladosporium par rapport à une autre solution identique ne contenant pas un sel de métal alcalino-terreux.

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