Viscosity-stable bismuth-containing pharmaceutical compositions

Details Viscosity-stable bismuth-containing pharmaceutical compositions Viscosity-stable bismuth-containing pharmaceutical compositions

A - Human Necessities

61

K

A61K 33/24 (2006.01) A61K 31/29 (2006.01) A61K 47/02 (2006.01) A61K 47/12 (2006.01) A61K 47/36 (2006.01) A61K 47/38 (2006.01) A61P 1/00 (2006.01) A61P 1/08 (2006.01) A61P 1/12 (2006.01)

Patent

CA 2534157

The present invention provides a pharmaceutical composition comprising at least 5 one pharmaceutically acceptable bismuth-containing compound, at least one pharmaceutically acceptable non-clay-derived suspending agent, water, and a stabilizing means for reducing viscosity change upon storage of the composition. The suspension exhibits reduced change in viscosity by comparison with an otherwise similar suspension excepting the stabilizing means. Such compositions are useful in the prevention and 10 treatment of gastrointestinal diseases and/or disorders

La présente invention se rapporte à une composition pharmaceutique comportant au moins un composé pharmaceutiquement acceptable contenant du bismuth, au moins un agent de suspension pharmaceutiquement acceptable autre que l'argile, de l'eau et un agent stabilisant permettant de réduire les variations de la viscosité de la composition pendant le stockage. La suspension présente des variations de viscosité réduites par rapport aux suspensions analogues qui ne comprennent pas l'agent stabilisant. De telles compositions sont utiles pour la prévention et le traitement de maladies/ou d'affections gastro-intestinales.

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