Therapeutic agents targeting the ncca-atp channel and...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/56 (2006.01) A61K 31/175 (2006.01)

Patent

CA 2580606

The present invention is directed to therapeutic compositions targeting the NCCa_ATPchannel of an astrocyte, neuron or capillary endothelial cell and methods of using same. More specifically, antagonists of the NCCa_ATPchannel are contemplated. The compositions are used to prevent cell death and to treat secondary damage associated with spinal cord injury.

Cette invention concerne des compositions thérapeutiques ciblant le canal NCCa_ATP d'une cellule astrocyte, d'une cellule nerveuse ou d'une cellule endhothéliale capillaires et leurs procédés d'utilisation. L'invention porte plus particulièrement sur des antagonistes de canal NCCa_ATP . Les compositions sont utilisées pour lutter contre la mort cellulaire et pour traiter les dommages secondaires relatifs aux lésions de la moelle épinière.

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