Cetp inhibitors

Details Cetp inhibitors Cetp inhibitors

C - Chemistry, Metallurgy

07

D

C07D 263/20 (2006.01) A61K 31/421 (2006.01) A61K 31/422 (2006.01) A61K 31/438 (2006.01) A61K 31/4439 (2006.01) A61K 31/454 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61K 31/541 (2006.01) A61K 31/55 (2006.01) A61P 9/10 (2006.01) C07D 413/06 (2006.01) C07D 413/10 (2006.01) C07D 413/12 (2006.01) C07D 417/10 (2006.01)

Patent

CA 2635010

Compounds having the structure of Formula (I), including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compounds of Formula (I), B or R2 is a phenyl group which has an ortho amine or aminomethyl substituent which is further substituted, and the other of B or R2 is also a cyclic group.

Des composés à structure de formule (I), y compris des sels pharmaceutiquement acceptables de ces composés, sont des inhibiteurs de CETP qui s'avèrent utiles pour augmenter le cholestérol HDL, réduire le cholestérol LDL, traiter ou prévenir l'athérosclérose. Dans les composés de formule (I), l'un des éléments B ou R2 est un groupe phényle doté d'un substituant ortho-amine ou aminométhyle lui-même substitué, l'autre élément B ou R2 étant aussi un groupe cyclique.

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