Indole carbamates as leukotriene antagonists

Details Indole carbamates as leukotriene antagonists Indole carbamates as leukotriene antagonists

C - Chemistry, Metallurgy

07

D

C07D 209/18 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 401/00 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01)

Patent

CA 2234239

A compound of formula (I) wherein R1 and R2 are as defined, is useful in the treatment of asthma, rheumatoid arthritis, osteoarthritis, bronchitis, chronic obstructive airways disease, psoriasis, allergic rhinitis, atopic dermatitis, shock, and other inflammatory diseases. Pharmaceutical compositions containing the compound and methods of blocking the leukotriene D4 receptor with the compound are also disclosed.

La présente invention concerne un composé représenté par la formule générale (I) où R?1¿ et R?2¿ sont conformes à leur définition dans les revendications. Ce composé sert à traiter l'asthme, la polyarthrite rhumatoïde, l'arthrose, la bronchite, les affections obstructives chroniques des voies aériennes, le psoriasis, la rhinite allergique, les dermatites atopiques, les chocs et autres affections inflammatoires. L'invention, qui concerne également des compositions pharmaceutiques contenant ces composés, concerne aussi des procédés de blocage du récepteur D4 du leukotriène au moyen de ce composé.

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