Ammonium salts of ornithine derivatives for treating...

Details Ammonium salts of ornithine derivatives for treating... Ammonium salts of ornithine derivatives for treating...

A - Human Necessities

61

K

A61K 31/519 (2006.01) A61P 1/00 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2534558

The present invention relates to pharmaceutically active ornithine compounds, particularly to pharmaceutically acceptable ammonium salts of N.delta.-acyl derivatives of N.alpha.(4-amino-4-deoxypteroyl)-L-ornithine compounds; and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such ammonium salts. The ammonium salts provided by the invention exhibit superior chemical stability than corresponding acidic N.delta.-acyl derivatives of N.delta.-acyl derivatives of N.alpha.(4-amino-4- deoxypteroyl)-L-ornithine compounds.

L'invention concerne des composés d'ornithine actifs sur le plan pharmaceutique, en particulier des sels d'ammonium de dérivés N?d¿-acyl de composés N?a¿ (4-amino-4-déoxyptéroyl)-L-ornithine ; ainsi que des méthodes de traitement et des compositions pharmaceutiques faisant intervenir ou comprenant un ou plusieurs desdits sels d'ammonium. Les sels d'ammonium de l'invention présentent une stabilité chimique supérieure par rapport aux dérivés N?d¿-acyl acides correspondants des dérivés N?d¿-acyl des composés N?a¿ (4-amino-4-déoxyptéroyl)-L-ornithine.

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