Temperature-sensitive liposomal formulation

Details Temperature-sensitive liposomal formulation Temperature-sensitive liposomal formulation

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61K 31/337 (2006.01) A61K 31/4745 (2006.01)

Patent

CA 2335250

Temperature sensitive liposomes containing active agents are described. The liposomes comprise phospholipids and a surface active agent, such as a lysolipid, that increases the amount of active agent released by the liposome at the phase transition temperature of the liposome. Such liposomes are useful in methods of administering active agents using mild hyperthermic conditions.

L'invention concerne des liposomes thermosensibles contenant des agents actifs. Ces liposomes contiennent des phospholipides et un agent de surface actif, tel qu'un lysolipide, qui augmente le taux d'agent actif libéré par le liposome lorsque ce dernier atteint sa température de changement de phase. Ces liposomes sont utiles dans des méthodes d'administration d'agents actifs en utilisant des conditions hyperthermiques.

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