C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/62 (2006.01) A61K 31/505 (2006.01) A61P 35/04 (2006.01) C07D 405/12 (2006.01)
Patent
CA 2442354
Compounds of formula I, wherein R1 represents a substituted or unsubstituted phenyl, phenoxy, phenylthio, phenylsulfenyl, phenylsufonyl, phenylamino or phenylmethyl residue, R2 is hydrogen, R3 represents hydrogen or alkyl, R4 represents alkyl, aryl, aralkyl, heteryl or acyl, and R2 and R3 and R4 form a piperazin ring which can be substituted, with metalloproteinase inhibitor activity.
L'invention concerne des composés représentés par la formule I, dans laquelle R1 représente un phényle, un phénoxy, un phénylthio, un phénylsulfényle, un phénylsufonyle, un phénylamino ou un reste de phénylméthyle, substitué ou non-substitué, R2 représente hydrogène, R3 représente hydrogène ou alkyle, R4 représente alkyle, aryle, aralkyle, hétéryle ou acyle, et R2 et R3 et R4 forment un noyau pipérazine qui peut être substitué; lesquels composés ont une activité inhibitrice de la métalloprotéinase.
Geppert Dagmar
Grams Frank
Krell Hans-Willi
Leinert Herbert
Menta Ernesto
F.hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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