Screening and selection methods for statin drug combinations

Details Screening and selection methods for statin drug combinations Screening and selection methods for statin drug combinations

C - Chemistry, Metallurgy

12

Q

C12Q 1/48 (2006.01) A61K 31/19 (2006.01) A61K 31/351 (2006.01) A61K 31/366 (2006.01) A61K 31/40 (2006.01) A61K 31/4418 (2006.01) A61K 31/505 (2006.01) A61K 45/00 (2006.01)

Patent

CA 2459926

A method for screening statins in their open acid form to determine the susceptibility of each tested statin to metabolic glucuronidation is provided. Also provided is a method for determining if a non-statin pharmaceutical drug co-administered with a statin that is susceptible to metabolic glucuronidation in its open acid form, will inhibit the glucuronidation of the statin and thereby increase the risk of an adverse drug interaction.

L'invention concerne une méthode destinée à l'analyse de statines sous leur forme acide ouverte, permettant de déterminer si chaque statine testée est susceptible d'induire une glucuronidation métabolique. L'invention concerne également une méthode permettant de déterminer si un médicament qui ne contient pas une statine, administré conjointement avec une statine susceptible d'induire une glucuronidation métabolique sous sa forme acide ouverte, va inhiber la glucuronidation de la statine et ainsi augmenter le risque d'une interaction médicamenteuse indésirable.

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