Staphylococcus aureus isd protein-based anti-infectives

Details Staphylococcus aureus isd protein-based anti-infectives Staphylococcus aureus isd protein-based anti-infectives

A - Human Necessities

61

K

A61K 39/40 (2006.01) A61K 31/7088 (2006.01) A61K 39/085 (2006.01) A61K 39/395 (2006.01) A61P 31/04 (2006.01) C12Q 1/14 (2006.01) C12Q 1/18 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2581746

Iron-regulated surface determinant proteins IsdA, IsdB and IsdC from Staphylococcus aureus, as well as antibodies, antisense nucleic acids and siRNA specific to IsdA, IsdB or IsdC are used as vaccines and in method for treating or preventing a disease or condition associated with S. aureus infections Screening assays for identifying agents that inhibit or interfere with the expression level and/or function of IsdA, IsdB or IsdC are also described.

L'invention concerne des nouveaux anti-infectieux qui agissent sur des gènes Isd ("iron-regulated surface determinants") de Staphylococcus aureus (S. aureus), IsdA, IsdB, et IsdC.

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