Human secreted proteins

Details Human secreted proteins Human secreted proteins

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 35/76 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2441840

The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating cardiovascular diseases, disorders, and/or conditions related thereto. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

Cette invention se rapporte à des polypeptides sécrétés humains, et à des molécules d'acide nucléique isolées codant ces polypeptides, qui sont utiles pour le diagnostic et le traitement des maladies cardio-vasculaires et des troubles et/ou états associés à ces maladies. Font également l'objet de cette invention des anticorps qui se fixent à ces polypeptides, ainsi que des vecteurs, des cellules hôtes et des procédés de recombinaison et de synthèse permettant de produire ces polynucléotides, ces polypeptides et/ou ces anticorps. Cette invention concerne en outre des procédés de criblage pour identifier des agonistes et des antagonistes de ces polynucléotides et polypeptides, ainsi que des procédés et des compositions pour inhiber ou améliorer la production et les fonctions de ces polypeptides.

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