C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 31/00 (2006.01) A61K 38/00 (2006.01) A61P 35/00 (2006.01) C12N 15/09 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/34 (2006.01) G01N 33/48 (2006.01) G01N 33/566 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2520415
The present invention relates to a method for screening and identifying compounds that modulate the activity tRNA splicing endonuclease. In particular, the invention provides assays for the identification of compounds that inhibit animalia tRNA splicing endonuclease. The methods of the present invention provide a simple, sensitive assay for high-throughput screening of libraries of compounds to identify pharmaceutical leads useful for treating and/or preventing cancer.
La présente invention se rapporte à un procédé de criblage et d'identification de composés modulant l'activité d'une endonucléase d'épissage d'ARNt. L'invention concerne plus particulièrement des essais d'identification de composés inhibant l'endonucléase d'épissage d'ARNt d'animaux. Les procédés de cette invention mettent à profit un essai simple et sensible en vue d'un criblage haut rendement de bibliothèques de composés permettant d'identifier des têtes de série pharmaceutiques que l'on utilise pour le traitement et/ou la prévention du cancer.
Osler Hoskin & Harcourt Llp
Ptc Therapeutics Inc.
LandOfFree
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