A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/45 (2006.01) A61K 31/00 (2006.01) A61K 31/05 (2006.01) A61K 31/5513 (2006.01) A61K 31/7048 (2006.01) A61K 31/7076 (2006.01)
Patent
CA 2486302
The present invention relates to the use of substrates of an UDP- glucuronosyltransferase (UGT) and salts thereof, for the prevention and /or the treatment of neurological disorders. In preferred embodiment, the present invention relates to the use of substrates of at least an UDP- glucuronosyltransferase (UGT) expressed in brain and salts thereof, for the prevention and /or the treatment of neurological disorders. It further relates to the use of said substrates, and salts thereof, for preventing and/or treating glutamate cytotoxicity, and more specifically of glutamate induced neurological disorders. Additionally, it concerns the use of said substrates, and salts thereof, for making drugs exerting an inhibitory effect on the release of glutamate.
L'invention concerne l'utilisation de substrats d'une UDP-glucuronosyltransférase (UGT) et de sels de ceux-ci pour la prévention et/ou le traitement de troubles neurologiques. Dans un mode de réalisation préféré, l'invention concerne l'utilisation de substrats d'au moins une UDP-glucuronosyltransférase (UGT) exprimée dans le cerveau et de sels de ceux-ci, pour la prévention et/ou le traitement de troubles neurologiques. L'invention concerne également l'utilisation de ces substrats et de sels de ceux-ci pour prévenir et/ou traiter la cytotoxicité due au glutamate, et plus spécifiquement des troubles neurologiques induits par le glutamate. En outre, l'invention concerne l'utilisation de ces substrats et de sels de ceux-ci pour fabriquer des médicaments exerçant un effet d'inhibition sur la libération de glutamate.
Faust Pharmaceuticals
Ridout & Maybee Llp
LandOfFree
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