C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/04 (2006.01) A61K 31/35 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/497 (2006.01) A61K 31/50 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) A61K 33/24 (2006.01) A61K 45/06 (2006.01) C07D 207/00 (2006.01) C07D 209/02 (2006.01) C07D 215/02 (2006.01) C07D 215/38 (2006.01) C07D 215/54 (2006.01) C07D 231/00 (2006.01) C07D 233/02 (2006.01) C07D 241/36 (2006.01) C07D 265/30 (2006.01) C07D 311/04 (2
Patent
CA 2447010
The present invention is directed to substituted 4H-chromenes and analogs thereof, represented by Formula (I) (see formula I) wherein R1-R5, A, Y and Z are defined herein. The present invention also relates to the discovery that compounds having Formula (I) are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which controlled growth and spread of abnormal cells occurs.
La présente invention concerne des chromènes substitués 4H et leurs analogues, représentés par la formule (I). Dans cette formule, R¿1?-R¿5?, A, Y et Z sont comme définis dans le descriptif. L'invention fait également apparaître que les composés de formule (I) sont des activateurs de caspases et des inducteurs d'apoptose. C'est pourquoi les activateurs de caspases et les inducteurs d'apoptose selon l'invention peuvent être utilisés pour induire la mort cellulaire dans diverses conditions cliniques caractérisées par une croissance sauvage et un prolifération de cellules anormales.
Cai Sui Xiong
Jiang Songchun
Storer Richard
Zhang Hong
Cytovia Inc.
Osler Hoskin & Harcourt Llp
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