Human sqm1 protein homolog comprising a cell adhesion protein

Details Human sqm1 protein homolog comprising a cell adhesion protein Human sqm1 protein homolog comprising a cell adhesion protein

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2270283

The present invention provides a polynucleotide which identifies and encodes a novel human SQM2. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding human SQM2. The invention also provides for the use of purified SQM2 and its agonists in the production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the expression of SQM2. Additionally, the invention provides for the use of SQM2 antagonists and inhibitors, including antisense molecules to SQM2 polynucleotides (i.e., gene sequences) in pharmaceutical compositions for the treatment of diseases associated with the expression of SQM2. The invention also describes diagnostic assays which utilize the polynucleotide to hybridize with the transcripts and/or genomic DNA encoding SQM2 and anti-human SQM2 antibodies which specifically bind to SQM2.

L'invention concerne un polynucléotide qui identifie une nouvelle protéine humaine, la SQM2, et code pour ladite protéine. Elle concerne également des vecteurs d'expression et des cellules hôtes mis au point par génie génétique, qui contiennent la séquence d'acide nucléiques codant pour la SQM2 humaine. Elle concerne aussi l'utilisation de la SQM2 purifiée et de ses agonistes dans la production de protéines recombinantes et dans des compositions pharmaceutiques destinées au traitement des maladies associées à l'expression de la SQM2. Elle concerne en outre l'utilisation d'antagonistes et d'inhibiteurs de la SQM2, notamment des molécules antisens par rapport aux polynucléotides SQM2 (c'est-à-dire des séquences géniques), dans des compositions pharmaceutiques destinées au traitement des maladies associées à l'expression de la SQM2. Elle concerne enfin des analyses diagnostiques qui utilisent le polynucléotide de façon qu'il s'hybride avec les transcripts et/ou l'ADN génomique codant pour la SQM2 et des anticorps anti-SQM2 humaine qui se fixent spécifiquement sur la SQM2.

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