Emulsions with free aqueous-phase surfactant as adjuvants...

A - Human Necessities – 61 – K

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A61K 39/39 (2006.01) A61K 39/145 (2006.01)

Patent

CA 2628158

A split influenza virus vaccine is adjuvanted with an oil-in-water emulsion that contains free surfactant in its aqueous phase. The free surfactant can continue to exert a 'splitting effect' on the antigen, thereby disrupting any unsplit virions and/or virion aggregates that might be present.

L'invention concerne un vaccin antigrippal sous-unitaire qui contient un adjuvant avec une émulsion renfermant un tensioactif dans sa phase aqueuse. Le tensioactif libre peut continuer d'exercer un "effet de division" sur l'antigène, ce qui disloque tous les virions non fendus et/ou les agrégats de virions susceptibles d'être présents.

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