Restoring function to gonadotropin releasing hormone...

Details Restoring function to gonadotropin releasing hormone... Restoring function to gonadotropin releasing hormone...

G - Physics

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G01N 33/566 (2006.01) A61K 31/46 (2006.01) A61K 31/4709 (2006.01) A61K 31/4725 (2006.01) A61K 31/506 (2006.01) A61K 31/7048 (2006.01) G01N 33/567 (2006.01) G01N 33/76 (2006.01)

Patent

CA 2514449

Methods are disclosed for screening for agents that can at least partially restore function to several mutant gonadotropin releasing hormone receptors (GnRHRs), which can increase cell-surface expression of wild-type GnRHR, or both. In addition, methods are provided for using the identified agents for treating subjects having hypogonadism.

L'invention porte sur des méthodes de criblage d'agents pouvant partiellement restaurer les fonctions de différents récepteurs mutants de l'hormone de libération de la gonadotrophine (GnRHR), car pouvant accroître l'expression par la surface cellulaire des GnRHR de type sauvage ou non. L'invention porte également sur des méthodes d'utilisation des agents ainsi identifiés pour traiter l'hypogonadisme.

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