C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07K 1/00 (2006.01) C07K 14/00 (2006.01) C12N 1/14 (2006.01) C12N 1/16 (2006.01) C12N 9/00 (2006.01) C12N 9/10 (2006.01) C12N 9/16 (2006.01) C12N 9/58 (2006.01) C12N 9/88 (2006.01) C12N 11/04 (2006.01) C12N 15/00 (2006.01) C12Q 1/18 (2006.01) G01N 33/53 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2469695
The present inventors have discovered that Asparagine Synthase, 5- Aminolevulinate synthase, histidinol-phosphatase, 3-Isopropylmalate dehydratase and Threonine synthase are essential for fungal pathogenicity. Specifically, the inhibition of Asparagine Synthase, 5-Aminolevulinate synthase, histidinol-phosphatase, 3-Isopropylmalate dehydratase or Threonine synthase gene expression in fungi results in no signs of successful infection or lesion. Thus, Asparagine Synthase, 5-Aminolevulinate synthase, histidinol- phosphatase, 3-Isopropylmalate dehydratase and Threonine synthase can be used as targets for the identification of antibiotics, preferably antifungals. Accordingly, the present inventio provides methods for the identification of compounds that inhibit Asparagine Synthase, 5-Aminolevulinate synthase, histidinol-hosphatase, 3-Isopropylmalate dehydratase or Threonine synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
La présente invention concerne l'asparagine synthase, la 5-aminolévulinate synthase, l'histidinol phosphatase, la 3-isopropylmalate déhydratase, la thréonine synthase qui sont essentielles en matière de pathogènicité fongique. Notamment, l'inhibition de l'expression génique de l'asparagine synthase, de la 5-aminolévulinate synthase, de l'histidinol phosphatase, de la 3-isopropylmalate déhydratase ou de la thréonine synthase dans des champignons ne débouche sur aucun signe de lésion ou d'infection réussie. Ainsi, on peut utiliser l'asparagine synthase, la 5-aminolévulinate synthase, l'histidinol phosphatase, la 3-isopropylmalate déhydratase ou la thréonine synthase en tant que cibles dans l'identification d'antibiotiques, de préférence, des antifongiques. Par conséquent, la présente invention a trait à des méthodes d'identification de composés qui inhibent l'expression ou l'activité de l'asparagine synthase, de la 5-aminolévulinate synthase, de l'histidinol phosphatase, de la 3-isopropylmalate déhydratase ou de la thréonine synthase. Ladite invention a également pour objet des méthodes utilisées dans l'identification d'antibiotiques, de préférence, d'antifongiques.
Adachi Kiichi
Darveaux Blaise A.
Dezwaan Todd M.
Frank Sheryl A.
Hamer Lisbeth
Icoria Inc.
Paradigm Genetics Inc.
Smart & Biggar
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