Methods to measure immunosuppressive tacrolimus, sirolimus,...

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G01N 33/94 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2602732

The present invention provides methods, diagnostic assays, and diagnostic kits based on said methods, to determine levels of immunosuppressive complexes containing immunosuppressive drugs tacrolimus, sirolimus and cyclosporine A separately and in combination, formed in the blood of a drug-treated patient or in a patient candidate to immunosuppressive drug therapy. These methods, assays and kits are especially useful when using automated systems.

L'invention concerne des procédés, des épreuves diagnostiques et des trousses diagnostiques basées sur lesdits procédés, qui permettent de déterminer les niveaux de complexes immunosuppresseurs contenant les médicaments immunosuppresseurs tracrolimus, sirolimus et cyclosporine A, séparément et combinés, qui se forment dans le sang d'un patient traité par lesdits médicaments ou chez un patient candidat à une thérapie par médicament immunosuppresseur.Les procédés, épreuves et trousses de l'invention sont particulièrement utiles lors de l'utilisation de systèmes automatisés.

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