A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/16 (2006.01) A61K 9/00 (2006.01)
Patent
CA 2502378
The present invention includes solid-state polypeptide particles containing a polypeptide material that is stabilized against degradation at temperatures that approximate or exceed physiological conditions. In each embodiment, the polypeptide particles of the present invention incorporate a polypeptide material that is stabilized against degradation by one or more stabilizing conditions. Because the polypeptide particles of the present invention can be formulated to combine the additive effects of two or\more stabilizing conditions, where the polypeptide particles of the present invention include a stabilizing sugar, the amount of stabilizing sugar needed to achieve acceptable polypeptide stability is significantly reduced.
La présente invention concerne des particules polypeptidiques solides contenant un matériau polypeptidique qui est stabilisé contre une dégradation à des températures proches des conditions physiologiques ou les dépassant. Dans chaque mode de réalisation, les particules polypeptidiques de cette invention incorporent un matériau polypeptidique qui est stabilisé contre une dégradation par une ou plusieurs conditions stabilisantes. Comme les particules polypeptidiques de cette invention peuvent être préparées pour combiner les effets additifs d'au moins deux conditions stabilisantes, lorsque ces particules polypeptidiques comprennent un sucre stabilisant, la quantité de sucre stabilisant nécessaire pour obtenir une stabilité suffisante est considérablement réduite.
Bentz Johanna
Kang Ling-Ling
Alza Corporation
Durect Corporation
Smart & Biggar
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