Inhibitors of serotonin reuptake

Details Inhibitors of serotonin reuptake Inhibitors of serotonin reuptake

A - Human Necessities

61

K

A61K 31/435 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) C07D 211/06 (2006.01) C07D 211/12 (2006.01) C07D 211/16 (2006.01) C07D 211/20 (2006.01) C07D 211/70 (2006.01) C07D 211/74 (2006.01) C07D 215/02 (2006.01) C07D 215/04 (2006.01) C07D 217/00 (2006.01) C07D 411/04 (2006.01) C07D 411/06 (2006.01) C07D 413/04 (2006.01) C07D 413/06 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2335322

A compound of Formula (I) where A-B is -C=CH- or -CHCH2-; n is 0 or 1; R1 is H or C1-C4 alkyl; R2 is H, methyl, or ethyl and Aryl is naphthyl or heteroaryl, each optionally monosubstituted with a substituent selected from the group consisting of H, halo, hydroxy, C1-C4 alkyl, C1-C4 alkoxy, cyano, nitro, carboaxamido, and trifluoromethyl; or pharmaceutically acceptable salts or hydrates thereof, provided that when n is 1, A-B is -CHCH2-, and a method for the inhibition of serotonin reuptake in mammals.

L'invention concerne un composé représenté par la formule (I), ou bien des sels ou des hydrates pharmaceutiquement acceptables dudit composé. Dans ladite formule, A-B est -C=CH- ou CHCH¿2?-; n vaut 0 ou 1 ; R?1¿ est H ou alkyle C¿1-4?; R?2¿ est H, méthyle ou éthyle ; et Aryle est naphtyle ou hétéroaryle, chacun éventuellement monosubstitué via un substituant qui fait partie de la liste suivante : H, halo, hydroxy, alkyle C¿1-4?, alcoxy C¿1-4?, cyano, nitro, carboxamido et trifluorométhyle, à condition que, lorsque n vaut 1, A-B est -CHCH¿2?-. L'invention concerne également un procédé relatif à l'inhibition de la réabsorption de la sérotonine chez les mammifères.

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