Indole orexin receptor antagonists

Details Indole orexin receptor antagonists Indole orexin receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 413/12 (2006.01) A61K 31/422 (2006.01) A61K 31/433 (2006.01) A61K 31/4439 (2006.01) A61K 31/4709 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2629192

The present invention is directed to substituted indole compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

La présente invention concerne des composés indoliques substitués qui sont des antagonistes des récepteurs de l~orexine. Ces composés sont utiles dans le traitement ou la prévention de pathologies neurologiques et psychiatriques et de maladies impliquant les récepteurs de l~orexine. Cette invention concerne également des compositions pharmaceutiques comprenant ces composés et l~utilisation de ces composés et compositions dans la prévention ou le traitement de maladies impliquant les récepteurs de l~orexine.

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